Learning Something ORIGINal at the Drosophila Neuromuscular Junction
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منابع مشابه
Learning Something ORIGINal at the Drosophila Neuromuscular Junction
Previews learning and memory mutants have morphological and leagues (Rohrbough et al., 1999) analyzes the synaptic phenotype of lat mutants. The most unexpected result is that the LAT protein is localized to synaptic boutons Genetic screens seek to identify molecules based on of the fly NMJ. While the staining intensity varies at phenotype, without regard to the expectations of the different sy...
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In an unbiased genetic screen designed to isolate mutations that affect synaptic transmission, we have isolated homozygous lethal mutations in Drosophila importin 13 (imp13). Imp13 is expressed in and around nuclei of both neurons and muscles. At the larval neuromuscular junction (NMJ), imp13 affects muscle growth and formation of the subsynaptic reticulum without influencing any presynaptic st...
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Parkinson's disease gene leucine-rich repeat kinase 2 (LRRK2) has been implicated in a number of processes including the regulation of mitochondrial function, autophagy and endocytic dynamics; nevertheless, we know little about its potential role in the regulation of synaptic plasticity. Here we demonstrate that postsynaptic knockdown of the fly homologue of LRRK2 thwarts retrograde, homeostati...
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BACKGROUND Cell-to-cell communication at the synapse involves synaptic transmission as well as signaling mediated by growth factors, which provide developmental and plasticity cues. There is evidence that a retrograde, presynaptic transforming growth factor-beta (TGF-beta) signaling event regulates synapse development and function in Drosophila. RESULTS Here we show that a postsynaptic TGF-be...
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Members of the Tre-2/Bub2/Cdc16 (TBC) family of proteins are believed to function as GTPase-activating proteins (GAPs) for Rab GTPases, which play pivotal roles in intracellular membrane trafficking. Although membrane trafficking is fundamental to neuronal morphogenesis and function, the roles of TBC-family Rab GAPs have been poorly characterized in the nervous system. In this paper, we provide...
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ژورنال
عنوان ژورنال: Neuron
سال: 1999
ISSN: 0896-6273
DOI: 10.1016/s0896-6273(00)80743-6